Antigen receptor triggering and apotopic pathways in neoplastic B cells

Authors	W.J.M. Mackus
Supervisors	M.H.J. van Oers R.A.W. van Lier
Cosupervisors	E.F. Eldering
Award date	13-11-2003
ISBN	90673404992
Number of pages	139
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Immunologie
Language	English
Downloads	Thesis Cover Titlepage CONTENTS CHAPTER 1 General Introduction CHAPTER 2 Prevention of B cell antigen receptor-induced apoptosis by ligation of CD40 occurs downstream of cell cycle regulation CHAPTER 3 B cell antigen receptor-induced apoptosis requires Bax and involves mitochondrial depolarization, cytochrome C release and caspase 9 activation CHAPTER 4 B cell receptor triggering reduces apotosis in B-CLL patients with unmutated lgVh genes and Zap -70 expression CHAPTER 5 Comprehensive profiling of apoptosis regulators in B-CLL reveals overexpression of Bmf and Noxa and links drug-induced Puma upregulation with IgVh status CHAPTER 6 Expansion of CMV-specific CD8⁺CD45RA⁺CD27⁻T cells in B-CLL CHAPTER 7 General discussion Summaries SAMENVATTING VOOR NIET INGEWIJDEN References ABBREVIATIONS PUBLICATIONS DANKWOORD CURRICULUM VITAE Cover
Permalink to this page

Back

UvA-DARE