Mutant ubiquitin and the proteasome in Alzheimer's disease

Authors	F.M.S. de Vrij
Supervisors	D.F. Swaab J. Verhaagen
Cosupervisors	E.M. Hol F.W. van Leeuwen
Award date	10-02-2005
ISBN	9080870536 9789080870536
Number of pages	183
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: NIH
Language	English
Downloads	Thesis Cover Titlepage Table of contents CHAPTER 1 Protein quality control in Alzheimer's disease by the ubiquitin proteasome system Scope and outline of this thesis CHAPTER 2 Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death CHAPTER 3 Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation CHAPTER 4 Critical levels of Alzheimer associated mutant ubiquitin cause a shift from substrate to inhibitor of the proteasome CHAPTER 5 A 40 and 42 peptides expressed in the cytosol are efficiently degraded and do not inhibit the proteasome CHAPTER 6 Discussion Summary Samenvatting References Color figures Abbreviations Curriculum vitae List of publications Dankwoord Cover
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