A mass spectrometric approach to investigate cardiolipin metabolism in Barth syndrome

Authors	F. Valianpour
Supervisors	R.J.A. Wanders P.G. Barth
Cosupervisors	A.H. van Gennip
Award date	17-09-2004
Number of pages	143
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: GEMO
Language	English
Downloads	Thesis Cover Titlepage CONTENTS ABBREVIATIONS CHAPTER 1 Introduction CHAPTER 2 Cardiolipin in health and disease and the importance of Tandem Mass Spectrometry CHAPTER 3 The Biochemical Basis of Barth syndrome is a Defect in Cardiolipin and Phosphatidylglycerol Remodeling CHAPTER 4 Quantitative and Compositional Study of Cardiolipin in Platelets by Electrospray Ionization Mass Spectrometry: Application for the Identification of Barth Syndrome Patients CHAPTER 5 Cardiolipin deficiency in X-linked cardioskeletal myopathy and neutropenia (Barth syndrome, MIM 302060): a study in cultured skin fibroblasts CHAPTER 6 Linoleic acid supplementation of Barth syndrome fibroblasts restores cardiolipin levels: implications for treatment CHAPTER 7 Monolysocardiolipins accumulate in Barth syndrome but do not lead to enhanced apoptosis CHAPTER 8 Only One Splice Variant of the Human TAZ Gene Encodes a Functional Protein with a Role in Cardiolipin Metabolism. CHAPTER 9 Aberrant cardiolipin metabolism in the yeast taz1 mutant: a model for Barth syndrome. CHAPTER 10 Summary and Prospects SAMENVATTING VOOR IEDEREEN Herinngeringwoord Cover
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