Interaction between inflammation, coagulation and fibrinolysis during infection

Thesis

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Titlepage

Contents

Chapter 1 Introduction and Outline of the Thesis

Chapter 2 Endogenous Interleukin 12 Improves the Early Antimicrobial Host Response to murine Escherichia coli Peritonitis

Chapter 3 Interleukin-18 Improves the Early Antimicrobial Host Response to Escherichia coli Peritonitis

Chapter 4 Diminished Interferon-y Production and Responsiveness after Endotoxin Administration to Healthy Humans

Chapter 5 Reduced interferon-y release in patients recovered from Legionnaires' disease

Chapter 6 Unimpaired Host Response of Platelet Activating Factor Receptor Deficient Mice during Pulmonary Tuberculosis

Chapter 7 Improved Host Defense against Pneumococcal Pneumonia in Platelet in Factor Receptor Deficient Mice

Chapter 8 Inhibition of the tissue factor-factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice

Chapter 9 Inhibition of the tissue factor-factor VIIa pathway in murine pneumococcal pneumonia

Chapter 10 Thrombomodulin influences the pulmonary immune response in murine tuberculosis

Chapter 11 Thrombomodulin mutant mice with a strongly reduced capacity to generate Activated Protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide

Chapter 12 Inhibition of plasmin activity by tranexamic acid does not influence inflammatory pathways during human endotoxemia

Chapter 13 Summary of the study results

Samenvatting en conclusies

Dankwoord

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