Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin
| Authors |
|
|---|---|
| Publication date | 2009 |
| Journal | Toxicon |
| Volume | Issue number | 53 | 6 |
| Pages (from-to) | 680-684 |
| Number of pages | 5 |
| Organisations |
|
| Abstract | Azaspiracid-2 was isolated from a marine sponge Echinoclathria sp. collected off Amami-Oshima as the predominant cytotoxic constituent. A combination of HPLC using ODS, GS320, and Phenylhexyl stationary phases permitted the purification without using acid or inorganic additives in the mobile phase. Azaspiracid-2 exhibited potent cytotoxicity against P388 cells with an IC50 value of 0.72 ng/mL and caused S phase arrest on the cell cycle. |
| Document type | Article |
| Language | English |
| Published at |
https://doi.org/10.1016/j.toxicon.2009.02.008
(Final published version)
|
| Permalink to this page | |