Allele specific inhibition. A novel approach to cancer therapy

Thesis

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Titlepage

CONTENTS

CHAPTER 1 INTRODUCTION

CHAPTER 2 GENETIC VARIATION IN mRNA CODING SEQUENCES OF HIGHLY CONSERVED GENES

CHAPTER 3 POLYMORPHISMS IN THE LARGE SUBUNIT OF HUMAN RNA POLYMERASE II AS TARGET FOR ALLELE-SPECIFIC INHIBITION

CHAPTER 4 TUMOR GENOTYPE SPECIFIC GROWTH INHIBITION IN VIVO BY ANTISENSE OLIGONUCLEOTIDES AGAINST A POLYMORPHIC SITE OF THE LARGE SUBUNIT OF HUMAN RNA POLYMERASE II

CHAPTER 5 THE EFFECT OF LOCKED NUCLEIC ACIDS ON ANTISENSE PHOSPHOROTHIOATE OLIGONUCLEOTIDES

CHAPTER 6 THE INVOLVEMENT OF HUMAN RIBONUCLEASES H1 AND H2 IN THE VARIATION OF RESPONSE OF CELLS TO ANTISENSE PHOSPHOROTHIOATE OLIGONUCLEOTIDES

CHAPTER 7 RIBONUCLEASE H2 MAPS TO CHROMOSOME 2 AND HAS AT LEAST THREE PSEUDOGENE LOCI IN THE HUMAN GENOME

SUMMARY

SAMENVATTING

DANKWOORD

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