T3, or no T3, that is the question : studies in the primary hypothydroidism and major depression

Thesis

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Stellingen behorend bij het proefschrift van Bente Cecille Appelhof

Titlepage

Contents

1 General Introduction

Studies in primary hypothyroidism

2 Cognitive functioning and well-being in euthyroid patients with thyroxine treated primary hypothyroidism

3 Combined therapy with T4 and T3 in two ratios compared with T4 monotherapy in primary hypothyroidism; a double blind, randomized controlled clinical trial

4 Polymorphisms in type II deiodinase and their association with well-being, neurocognitive functioning and preference for combined T4/T3 therapy

Studies in major depression

5 Thyroid and adrenal axis in major depression: a study in outpatients

6 Triiodothyronine (T3) addition to paroxetine in the treatment of major depressive disorder

7 Thyrotropin, but not a polymorphism in type II deiodinase, predicts response to paroxetine in major depression

8 Prediction of treatment response by HPA axis and glucocorticoid receptor polymorphisms in major depression

9 Glucocorticoids and relapse in major depression

10 General Discussion

Summary

Samenvatting

Dankwoord

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