Mechanisms of immune activation during infection

Thesis

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Titlepage

Contents

CHAPTER 1 Introduction and outline of the thesis

CHAPTER 2 Human endotoxemia activates p38 MAP kinase and p42/44 MAP kinase, but not c-Jun N-terminal Kinase

CHAPTER 3 Anti-inflammatory effects of a p38 Mitogen Activated Protein Kinase inhibitor during human endotoxemia

CHAPTER 4 Inhibition of coagulation, fibrinolysis and endothelial cell activation by a p38 Mitogen Activated Protein Kinase inhibitor during human endotoxemia

CHAPTER 5 P38 Mitogen Activated Protein Kinase is involved in the downregulation of granulocyte CXC chemokine receptors 1 and 2 during human endotoxemia

CHAPTER 6 Lipopolysaccharide binding protein deficient mice have a normal defense against pulmonary mycobacterial infection

CHAPTER 7 Toll-like receptor 4 plays a protective role in pulmonary tuberculosis in mice

CHAPTER 8 Lipopolysaccharide binding protein deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia

CHAPTER 9 The role of Toll-like receptor 4 in Gram-positive and Gram-negative pneumonia in mice

CHAPTER 10 IL-18 improves the early antimicrobial host response to pneumococcal pneumonia

CHAPTER 11 Platelet activating factor receptor deficient mice have an unaltered host defense against non-typeable Haemophilus influenzae pneumonia

CHAPTER 12 Summary & discussion

SAMENVATTING

Dankwoord

Curriculum vitae

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