Mechanisms of arteriogenesis: from cellular adhesion to therapeutic stimulation

Thesis

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Titlepage

CONTENTS

1 INTRODUCTION AND OUTLINE

2 DIRECT EVIDENCE FOR TNF-α SIGNALING IN ARTERIOGENESIS

3 ANTI-TUMOR NECROSIS FACTOR-ALPHA THERAPIES ATTENUATE ADAPTIVE ARTERIOGENESIS

4 LEUKOCYTE SUBPOPULATIONS AND ARTERIOGENESIS: SPECIFIC ROLE OF MONOCYTES, LYMPHOCYTES AND GRANULOCYTES

5 ARTERIOGENESIS PROCEEDS VIA ICAM-1/MAC-1 MEDIATED MECHANISMS

6 CD44 REGULATES ARTERIOGENESIS IN MICE AND IS DIFFERENTIALLY EXPRESSED IN PATIENTS WITH POOR AND GOOD COLLATERALIZATION

7 TIME COURSE OF ARTERIOGENESIS FOLLOWING FEMORAL ARTERY OCCLUSION IN THE RABBIT

8 GM-CSF: A STRONG ARTERIOGENIC FACTOR ACTING BY AMPLIFICATION OF MONOCYTE FUNCTION

9 EXOGENOUS APPLICATION OF TRANSFORMING GROWTH FACTOR-BETA 1 STIMULATES ARTERIOGENESIS IN THE PERIPHERAL CIRCULATION

10 EFFECTS OF LOCAL MCP-1 PROTEIN THERAPY ON THE DEVELOPMENT OF THE COLLATERAL CIRCULATION AND ATHEROSCLEROSIS IN WATANABE HYPERLIPIDEMIC RABBITS

11 LOCAL MONOCYTE CHEMOATTRACTANT PROTEIN-1 THERAPY INCREASES COLLATERAL ARTERY FORMATION IN APOLIPOPROTEIN-E DEFICIENT MICE BUT INDUCES SYSTEMIC MONOCYTIC CD11B EXPRESSION, NEOINTIMA FORMATION AND PLAQUE PROGRESSION

12 DIVERGENT EFFECTS OF ANTI-PLATELET DRUGS ON ARTERIOGENESIS AFTER FEMORAL ARTERY OCCLUSION IN THE RABBIT HINDLIMB

13 SUMMARY AND CONCLUSIONS

14 SAMENVATTING EN CONCLUSIES

DANKWOORD

CURRICULUM VITAE

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