para-Selective C-H Olefination of Aniline Derivatives via Pd/S,O-Ligand Catalysis
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| Publication date | 24-04-2019 |
| Journal | Journal of the American Chemical Society |
| Volume | Issue number | 141 | 16 |
| Pages (from-to) | 6719-6725 |
| Number of pages | 7 |
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| Abstract | Herein we report a highly para-selective C-H olefination of aniline derivatives by a Pd/S,O-ligand-based catalyst. The reaction proceeds under mild reaction conditions with high efficiency and broad substrate scope, including mono-, di-, and trisubstituted tertiary, secondary, and primary anilines. The S,O-ligand is responsible for the dramatic improvements in substrate scope and the high para-selectivity observed. This methodology is operationally simple, scalable, and can be performed under aerobic conditions. |
| Document type | Article |
| Note | With supplementary file |
| Language | English |
| Published at | https://doi.org/10.1021/jacs.9b01908 |
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