Cytokines and chemokines in systemic and urinary tract infection by Escherichia coli

Thesis

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Titlepage

Contents

Chapter 1 General introduction and outline of the thesis

Chapter 2 Interleukin-8, but not interleukin-6, is elevated in urine of postoperative patients with urinary tract infection.

Chapter 3 Urine and serum levels of inhibitors of tumor necrosis factor-α and interleukin 1 ß in patients with urosepsis.

Chapter 4 Sequential measurements of CC chemokines in urosepsis and experimental endotoxemia.

Chapter 5 Chemotactic activity of CXC chemokines interleukin (IL)-8, growth-related oncogene (GRO)a and epithelial cell-derived neutrophil-activating protein (ENA)-78 in urine of patients with urosepsis.

Chapter 6 CXC chemokine receptor 2 (CXCR2) contributes to host defense in murine urinary tract infection.

Chapter 7 Induction of cell-associated chemokines after endotoxin administration to healthy humans.

Chapter 8 IC14, an Anti-CD14 Antibody, Inhibits Rises in Plasma and Cell-AssociatedChemokines in Human Endotoxemia.

Chapter 9 Reduced Ex Vivo Chemokine Production by Polymorphonuclear Cells after In Vivo Exposure of Normal Humans to Endotoxin.

Chapter 10 Interleukin 10 inhibits the release of CC chemokines during human endotoxemia.

Chapter 11 Effect of interleukin (IL-)10 on the release of the CXC chemokines growth-regulated oncogene (GRO)-a and epithelial-cell-derived neutrophil-activating peptide (ENA)-78 during human endotoxemia.

Chapter 12 Enhanced Bacterial Clearance but Increased Mortality of Interleukin 10 deficient Mice after Escherichia coli Peritonitis

Chapter 13 Summary and General Discussion

Nederlandse Samenvatting

Addendum

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