Molecular mechanisms of complement activation by damaged cells

Thesis

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Titlepage

CONTENTS

CHAPTER I INTRODUCTION

CHAPTER II MOLECULAR MECHANISMS OF COMPLEMENT ACTIVATION DURING ISCHEMIA AND REPERFUSION

CHAPTER III Complement activation by apoptotic cells in normal plasma occurs predominantly via IgM and is limited to late apoptotic (secondary necrotic) cellsa.

Chapter IV Complement activation by necrotic cells in normal plasma environment compares to that by late apoptotic cells and involves predominantly IgM. Complement activation by necrotic and apoptotic cells

CHAPTER V Competitive binding of pentraxins and IgM to newly exposed epitopes on late apoptotic cells.

CHAPTER VI Levels of natural IgM antibodies against phosphorylcholine in healthy individuals and in patients undergoing isolated limb perfusion.

CHAPTER VII IgM co-localizes with complement and C-reactive protein in the infarcted human myocardium IgM localizes in the infarcted human heart.

CHAPTER VIII Relation of IgM antibodies against apoptotic cells and phosphorylcholine to the inflammatory response and infarct size in patients with acute myocardial infarction.

CHAPTER IX Jurkat cells exposed to metabolic inhibitors as an in vitro model for I/R injury

CHAPTER X SUMMARIZING DISCUSSION

Algemene discussie

Discussion générale

Acknowledgements

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