Guideline development for the prevention of surgical site infections

Surgical site infections (SSI) are a common postoperative complication with significant impact on patient outcomes. This thesis investigates various preventive measures for SSI through seven studies. Two network meta-analyses are conducted on bowel preparation and preoperative skin antiseptics. The thesis also includes meta-analyses on the effectiveness of hemodynamic management during surgery, different wound irrigation solutions, and the use of triclosan-coated sutures in reducing SSI. Additionally, an individual participant data meta-analysis examines the effect of door openings in the operating room on SSI risk. The findings provide evidence-based recommendations to improve clinical practices in SSI prevention.