Splenic studies: prevention of pneumococcal disease on organisational, clinical and experimental level

Splenic studies: prevention of pneumococcal disease on organisational, clinical and experimental level

Authors	A.J.J. Lammers
Supervisors	P. Speelman T. van der Poll
Cosupervisors	J.B.L. Hoekstra M.J.M.H. Lombarts
Award date	01-11-2011
ISBN	9789085708599
Number of pages	160
Organisations	Faculty of Medicine (AMC-UvA)
Abstract	Jolanda Lammers onderzocht de preventie van ernstige infecties met gekapselde bacteriën, zoals de pneumokok, bij patiënten zonder milt (asplenie). Zij blijken in Nederland onvoldoende gevaccineerd te worden en krijgen zelden antibiotica voorgeschreven. Deze patiënten komen hiervoor in aanmerking, maar de miltfunctie blijkt lastig te meten. Het bacteriële kapsel is verantwoordelijk, zo tonen dierproeven aan, voor ernstige infecties bij asplenie.
Document type	PhD thesis
Language	English
Downloads	Thesis Cover Title pages Contents Chapter 1: General introduction and outline of this thesis Chapter 2: Management of post-splenectomy patients in the Netherlands Chapter 3: Performance of Dutch hospitals in the management of splenectomized patients Chapter 4: Physicians report barriers to deliver best practice care for asplenic patients: a cross-sectional survey Chapter 5: Recommendations to prevent severe infection in patients with asplenia or hyposplenia Chapter 6: Assessment of splenic function (review) Chapter 7: How to diagnose hyposplenia: comparison of different functional tests Chapter 8: Enhanced vulnerability for Streptococcus pneumoniae sepsis during asplenia is determined by the bacterial capsule Chapter 9: The role of TLR2 in the host response to pneumococcal pneumonia in absence of the spleen Summary and general discussion Nederlandse samenvatting List of publications Dankwoord Curriculum vitae
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Splenic studies: prevention of pneumococcal disease on organisational, clinical and experimental level