Genetic and biochemical riks factors in coronary artery disease

Thesis

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Titlepage

Contents

1 General introduction and outline of the thesis

2 Molecular variation at the apolipoprotein B gene locus in relation to lipids and cardiovascular disease; a systematic meta-analysis

3 The ratio of apolipoproteins B to A-I and the risk of future coronary artery disease in apparently healthy men and women; the EPIC-Norfolk prospective population study

4 CETP gene variation; relation to lipid parameters and cardiovascular risk

5 The cholesteryl ester transfer protein (CETP) TaqIB variant, HDL cholesterol levels, cardiovascular risk and the efficacy of pravastatin treatment – an individual patient meta-analysis of 13,677 subjects

6 Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women; the prospective EPIC-Norfolk population study

7 CETP, HDL-c, and cardiovascular risk: Will CETP inhibition translate into cardiovascular risk reduction?

8 Serum levels of type II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women; the EPIC-Norfolk prospective population study

9 Variants of the toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events

10 IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women; the EPIC-Norfolk prospective population study

11 Plasma concentration of macrophage migration inhibitory factor and the risk of future myocardial infarction or coronary artery disease death in men and women without prior myocardial infarction or stroke; the EPIC-Norfolk prospective population study

12 C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women; the EPIC-Norfolk prospective population study 1993-2003

13 Interaction between a genetic variant of the platelet fibrinogen receptor and fibrinogen levels in determining the risk of cardiovascular events

14 Genetic variation in coagulation and fibrinolytic proteins and their relation with acute myocardial infarction; a systematic review

15 Fibrinogen plasma levels, the factor XIII VaI34Leu variant and the risk of future coronary artery disease; the EPIC-Norfolk prospective population study

Summary and conclusion

Samenvatting en conclusie

List of publications

Dankwoord

Curriculum vitae

Stellingen behorend bij het proefschrift

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