Pros en cons of natural and recombinant allergens

Authors	E. van Oort
Supervisors	R.C. Aalberse
Cosupervisors	R. van Ree
Award date	19-09-2003
Number of pages	214
Organisations	Faculty of Science (FNWI) - Swammerdam Institute for Life Sciences (SILS)
Document type	PhD thesis
Note	Research conducted at: Sanquin
Downloads	Thesis Cover Titlepage Contents Abbreviations Chapter 1 General Introduction Chapter 2 Characterization of natural Dac g 1 variants: an alternative to recombinant group 1 allergens Chapter 3 The major grass pollen group 5 allergen from Dactylis glomerata and its C-terminal split-product both behave as dimers: implications for allergen standardization Chapter 4 Immunochemical characterization of two Pichia pastoris derived recombinant group 5 Dactylis glomerata isoallergens. Chapter 5 Maturation of Pichia pastoris-derived recombinant pro-Der p 1 induced by deglycosylation and by the natural cysteine protease Der p 1 from house dust mite. Chapter 6 Substitution of Pichia pastoris-derived recombinant proteins with mannose containing O- and N-linked glycans decreases specificity of diagnostic tests. Chapter 7 Poor biological activity of N-glycan reactive IgE is due to low avidity. A study with glycosylated mutant Der p 2 and neoglycopeptides. Chapter 8 Summary Samenvatting in het nederlands Dankwoord Curriculum vitae Cover
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