Pathomorphological and physiological characteristics of coronary artery disease

Thesis

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STELLINGEN BIJ HET PROEFSCHRIFT

Titlepage

CONTENTS

1 Introduction and outline

Part I Pathology of coronary plaques

2 Complex coronary artery stenosis and unstable angina are positively associated with the extent of plaque inflammation

3 Plaque inflammation in restenotic coronary lesions of patients with stable or unstable angina

4 "Stent inflammation" Stent-footprint in restenotic tissue retrieved by directional atherectomy

5 Intraplaque C-reactive protein associates with the severity of acute coronary syndromes

6 Recurrent unstable angina following directional coronary atherectomy relates to the extent of initial coronary plaque inflammation

Part II Coronary Pathophysiology

7 Fractional flow reserve, absolute and relative coronary blood flow velocity reserve in relation to the results of technetium-99m sestamibi single-photon emission computed tomography in patients with two-vessel coronary artery disease

8 Role of variability in microvascular resistance on fractional flow reserve and coronary blood flow velocity reserve in intermediate coronary lesions

9 The association between coronary lesion severity and distal microvascular resistance in patients with coronary artery disease

10 Hyperemic stenosis resistance index for evaluation of functional coronary lesion severity

11 The prognostic value of combined intracoronary pressure and blood flow velocity measurements for clinical decision making in patients with intermediate coronary lesions

12 The additional value of C-reactive protein in patients with intermediate coronary lesions and a normal fractional flow reserve

13 Summary and conclusions

14 Samenvatting en conclusies

Dankwoord

Curriculum Vitae

List of publications

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