Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

Open Access
Authors
  • G.T. Höfler
  • A. But
  • S.H.H. Younes
  • R. Wever
  • C.E. Paul
  • I.W.C.E. Arends
  • F. Hollmann
Publication date 24-02-2020
Journal ACS Sustainable Chemistry & Engineering
Volume | Issue number 8 | 7
Pages (from-to) 2602-2607
Number of pages 6
Organisations
  • Faculty of Science (FNWI) - Van 't Hoff Institute for Molecular Sciences (HIMS)
Abstract The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.
Document type Article
Note With supplementary file
Language English
Published at https://doi.org/10.1021/acssuschemeng.9b07494
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acssuschemeng.9b07494 (Final published version)
Supplementary materials
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