In vivo signal transduction: mitogen activated protein kinases in inflammation

Authors	B. van den Blink
Supervisors	S.J.H. van Deventer
Cosupervisors	M.P. Peppelenbosch T. van der Poll
Award date	11-09-2002
ISBN	9090160124 9789090160122
Number of pages	176
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: CLDO
Language	English
Downloads	Thesis Cover Stellingen behorende bij het proefschrift Titlepage CONTENTS Chapter 1 General introduction Chapter 2 Human endotoxemia activates p38 MAP kinase and p42/44 MAP kinase, but not c-Jun N-terminal Kinase Chapter 3 Anti-inflammatory effects of a p38 Mitogen Activated Protein Kinase inhibitor during human endotoxemia Chapter 4 P38 MAPK is involved in the downregulation of granulocyte CXCR 1 and 2 during human endotoxemia Chapter 5 Inhibition of coagulation, fibrinolysis and endothelial cell activation by a p38 Mitogen-Activated Protein kinase inhibitor during human endotoxemia Chapter 6 Inhibition of Stress-Activated MAP Kinases induces clinical improvement in moderate to severe Crohn's disease Chapter 7 Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis. Chapter 8 p38 MAP kinase inhibition increases cytokine release by macrophages in vitro and during infection in vivo Chapter 9 p42/44 MAPK mediates the inflammatory response to Streptococcus pneumoniae in vitro and in vivo Chapter 10 Summary & Discussion Samenvatting Dankwoord Bibliography Curriculum vitae References Cover
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