Ventilator induced lung injury in models of neonatal respiratory failure. The role lung protective ventilation and surfactant

Authors	A.H.L.C. van Kaam
Supervisors	B. Lachmann J.H. Kok
Cosupervisors	J.J. Haitsma
Award date	07-04-2004
ISBN	9090178430 9789090178431
Number of pages	159
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Incorrect PhD defence date on title page. Research conducted at: AmCOGG
Language	English
Downloads	Thesis Cover Titlepage Contents Chapter 1 Introduction Treatment of respiratory failure in newborn infants The role of mechanical ventilation and surfactant Chapter 2 Outline of this thesis Chapter 3 Positive pressure ventilation with the open lung concept optimizes gas exchange and reduces ventilator-induced lung injury in newborn piglets Chapter 4 Application of the open lung concept during positive pressure ventilation reduces pulmonary inflammation in newborn piglets Chapter 5 The response to exogenous surfactant is different during open lung and conventional ventilation Chapter 6 Open lung ventilation improves gas exchange and attenuates secondary lung injury in a piglet model of meconium aspiration Chapter 7 Surfactant attenuates bacterial growth and translocation in experimental streptococcal pneumonia Chapter 8 Effect of exogenous surfactant and ventilation strategy on local and systemic inflammatory markers in experimental streptococcal pneumonia Chapter 9 Summary, conclusions and future perspectives Chapter 10 Samenvatting, conclusies en aanbevelingen Dankwoord Curriculum Vitae Stellingen Cover
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