HIV-1 gene expression: characterization of viruses with altered transcription elements

Authors	K.D. Verhoef
Supervisors	J. Goudsmit
Cosupervisors	B. Berkhout
Award date	12-03-1999
Number of pages	155
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: INFECT
Language	English
Downloads	Thesis Cover Titlepage Contents Chapter 1: Introduction: Transcriptional regulation of HIV-1. Chapter 2: Optimal Tat-mediated activation of the HIV-1 LTR promoter requires a full-length TAR hairpin. Chapter 3: Paracrine activation of the HIV-1 LTR promoter by the viral Tat protein is mechanistically similar to transactivation within a cell. Chapter 4: On the role of the second coding exon of the HIV-1 Tat protein in virus replication and MHC class 1 downregulation. Chapter 5: Determination of the minimal amount of Tat activity required for Human Immunodeficiency Virus type 1. replication. Chapter 6: A second-site mutation that restores replication of a Tat-defective Human Immunodeficiency Virus. Chapter 7: Evolution of the HIV-1 LTR promoter by conversion of an NF-kB enhancer element into a GABP binding site. Chapter 8: Genetic instability of live attenuated HIV-1 vaccine strains. Summary Samenvatting Dankwoord Curriculum Vitae Cover
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