Photoinduced Intermolecular Radical Hydroalkylation of Olefins via Ligated Boryl Radicals-Mediated Halogen Atom Transfer
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| Publication date | 12-07-2024 |
| Journal | Organic Letters |
| Volume | Issue number | 26 | 27 |
| Pages (from-to) | 5839-5843 |
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| Abstract | Light-mediated Halogen-Atom Transfer (XAT) has become a significant methodology in contemporary synthesis. Unlike α-aminoalkyl and silyl radicals, ligated boryl radicals (LBRs) have not been extensively explored as halogen atom abstractors. In this study, we introduce NHC-ligated boranes as optimal radical chain carriers for the intermolecular reductive radical hydroalkylation and hydroarylation of electron-deficient olefins by using direct UV-A light irradiation. DFT analysis allowed us to rationalize the critical role of the NHC ligand in facilitating efficient chain propagation. |
| Document type | Article |
| Note | cited By 0 |
| Language | English |
| Published at | https://doi.org/10.1021/acs.orglett.4c02034 |
| Other links | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197445119&doi=10.1021%2facs.orglett.4c02034&partnerID=40&md5=fe122184318788481412baba7b30748c |
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Photoinduced Intermolecular Radical Hydroalkylation of Olefins
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