Sickle cell disease, pathophysiology and clinical complications

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Thesis

Cover

Titlepage

Table of Contents

Part I: General overview and clinical complications

1: Pathophysiology and treatment of sickle cell disease

2: Patient-controlled analgesia versus continuous infusion of morphine during vaso-occlusive crises in sickle cell disease, a randomized controlled trial

3: Sickle cell disease-related organ damage occurs irrespective of pain rate: implications for clinical practice

4: Normal sublingual microcirculation during painful crises in sickle cell disease

Part II: Pathophysiology

5: Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease

6: Sickle cell patients are characterized by a reduced glycocalyx volume

Part III: Pulmonary hypertension

7: Large and medium-sized pulmonary artery obstruction does not play a role of primary importance in the etiology of sickle cell disease-associated pulmonary hypertension

8: No association of the hypercoagulable state with sickle cell disease related pulmonary hypertension

9: Association of asymmetric dimethylarginine with sickle cell disease related pulmonary hypertension

10: Cardiopulmonary imaging, functional and laboratory studies in sickle cell disease associated pulmonary hypertension

11: Decreased excercise tolerance and pulmonary hypertension in patients with sickle cell disease

12: Summary

13: Dankwoord

14: Curriculum Vitae