Catalytic enantioselective addition of methyltriisopropoxititanium to aldehydes
| Authors |
|
|---|---|
| Publication date | 15-08-2016 |
| Journal | Tetrahedron-Asymmetry |
| Volume | Issue number | 27 | 14-15 |
| Pages (from-to) | 643-648 |
| Organisations |
|
| Abstract | An efficient catalyst for the enantioselective synthesis of chiral methyl carbinols from aldehydes is presented. The system uses methyltriisopropoxytitanium as a nucleophile and a readily available binaphthyl derivative as a chiral ligand. The enantioselective methylation of both aromatic and aliphatic aldehydes proceeds with good yields and high enantioselectivities under mild conditions. |
| Document type | Article |
| Note | With supplementary file |
| Language | English |
| Published at | https://doi.org/10.1016/j.tetasy.2016.06.001 |
| Downloads |
1-s2.0-S0957416616300891-main
(Final published version)
|
| Supplementary materials | |
| Permalink to this page | |