Divergent Total Syntheses of Yaequinolone-Related Natural Products by Late-Stage C-H Olefination
| Authors | |
|---|---|
| Publication date | 07-05-2021 |
| Journal | Journal of Organic Chemistry |
| Volume | Issue number | 86 | 9 |
| Pages (from-to) | 6259-6277 |
| Number of pages | 19 |
| Organisations |
|
| Abstract | Divergent total syntheses of 10 yaequinolone-related natural products have been achieved for the first time by latestage C-H olefination of 3,4-dioxygenated 4-aryl-5-hydroxyquinolin-2(1H)-ones, core structures of this family of natural products. A robust synthetic methodology to construct the core structures has been established, and the C-H olefination reaction has been carried out with synthetically useful yields and high levels of site-selectivity under mild reaction conditions in the presence of a Pd/S,O-ligand catalyst. |
| Document type | Article |
| Note | With supplementary material. |
| Language | English |
| Published at | https://doi.org/10.1021/acs.joc.1c00042 |
| Downloads |
acs.joc.1c00042 (1)
(Final published version)
|
| Supplementary materials | |
| Permalink to this page | |