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  2. Modulation of regulatory of mechanisms of intestinal ion secretion by TNFa and NPY

Modulation of regulatory of mechanisms of intestinal ion secretion by TNFa and NPY

Open Access
Authors
  • J.C.J. Oprins
Supervisors
  • F.H. Lopes da Silva
Cosupervisors
  • J.A. Groot
Award date 08-02-2001
Number of pages 191
Organisations
  • Faculty of Science (FNWI) - Swammerdam Institute for Life Sciences (SILS)
Document type PhD thesis
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Contents
Abbreviations
Abstract
Chapter One General introduction
Part I TNFa
Chapter Two TNFa potentiates the ion secretion induced by muscarinic receptor activation in HT29cl.19A cells
Chapter Three The PLD pathway is involved in the carbachol-induced CT secretion; possible role of TNFa
Chapter Four Comparison of the potentiating effect of TNFa of the muscarinic receptor activated ion secretion in human colon cell lines and distal colon of mice
Chapter Five TNFa potentiates ion secretion induced by histamine in a human intestinal epithelial cell line and in mouse distal colon: involvement of the PLD pathway
Part II NPY
Chapter Six Neuropeptide Y inhibits ion secretion in intestinal epithelium by reducing chloride and potassium conductance
Chapter Seven Neuropeptide Y inhibits the PKC-stimulated CT secretion in human colonocytes via multiple sites
Chapter Eight Summarizing discussion
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