Circadian system rhythm disorders in aging and Alzheimer's disease. Role of changes in melatonin, suprachiasmatic nucleus and corticosteroids

Authors	R-Y. Liu
Supervisors	D.F. Swaab
Award date	04-07-2001
ISBN	9090148930 9789090148939
Number of pages	144
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Geneeskunde, NPA
Language	English
Downloads	Thesis Cover Titlepage Table of contents CHAPTER 1 General Introduction CHAPTER 2 Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease and ApoEε 4/4 genotype CHAPTER 3 The first appearance of neurofibrillary tangles and plaques in the temporal cortex of aged controls is accompanied by decreased cerebrospinal fluid melatonin levels CHAPTER 4 Alterations in the circadian rhythm of salivary melatonin start already at middle-age CHAPTER 5 Decreased vasopressin gene expression in the biological clock of Alzheimer's disease patients with and without depression CHAPTER 6 Glucocorticoids Suppress Vasopressin Gene Expression in the Human Biological Clock CHAPTER 7 Influence of academic stress on circadian rest-activity and sleep-wake rhythm of female students CHAPTER 8 General Discussion REFERENCES (CHAPTERS 1 AND 8) SUMMARY SAMENVATTING ACKNOWLEDGMENTS CURRICULUM VITAE Cover
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