IL-12, IL-18 and IFN-gamma in the immune response to bacterial infection

Thesis

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Titlepage

Contents

Chapter 1 General introduction and Outline of the thesis

Chapter 2 The role of interleukin-12 (IL-12) and IL-18 during endotoxemia and bacterial infection

Chapter 3 Interleukin-12 induces sustained activation of multiple host inflammatory mediator systems in chimpanzees

Chapter 4 Activation of mononuclear cells by interleukin-12: an in vivo study in chimpanzees

Chapter 5 Role of endogenous IL-12 in the immune response to staphylococcal enterotoxin B in mice

Chapter 6 IL-18 has a protective role in the early antimicrobial host response to pneumococcal pneumonia

Chapter 7 The role of interferon-y in murine pneumococcal pneumonia

Chapter 8 Interferon- treatment has no beneficial effect during Mycobacterium avium complex infection in HIV-infected patients

Chapter 9 Reduced Th1, but not Th2, cytokine production by lymphocytes after in vivo exposure of healthy subjects to endotoxin

Chapter 10 Elevated plasma concentrations of interferon-y (IFN-y) and the IFN-y-inducing cytokines interleukin-18 (IL-18), IL-12 and IL-15 in severe melioidosis

Chapter 11 The CXC chemokines interferon- -inducible protein-10 (IP-10) and monokine induced by IFN- (Mig) are released during severe gram-negative bacterial infection

Chapter 12 Soluble granzymes are released during human endotoxemia and in patients with severe gram-negative bacterial infection

Chapter 13 Proinflammatory effects of IL-10 during human endotoxemia

Chapter 14 Epinephrine inhibits the production of interferon- and interleukin-12 in whole blood stimulated with endotoxin

Chapter 15 Summary and General discussion

Samenvatting

Addendum

Dankwood

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