Klinische en farmacologische studies met artemether voor de behandeling van malaria

Thesis

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Titlepage

Contents

1: Outline of this thesis

2: Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication

3: Validation of an improved reversed-phase HPLC assay with reductive electrochemical detection for the determination of artemisinin derivatives in man

4: The development of an immunoassay for the detection of artemisinin compounds in urine

5: Some pharmacokinetic and -dynamic comparisons of artemisinin derivatives in man

6: Multiple dose pharmacokinetics of artemether in Chinese patients with uncomplicated falciparum malaria

7: The comparative efficacy and tolerability of CGP 56697 (artemether + lumefantrine) versus halofantrine in the treatment of uncomplicated falciparum malaria in travellers returning from The Tropics to The Netherlands and France.

8: The contribution of the enzymes CYP2D6 and CYP2C19 in the demethylation of artemether in healthy subjects

9: Grapefruit juice increases the bioavailability of artemether

10: The effect of grapefruit juice on the time-dependent decline of artemether plasma levels in healthy subjects

11: Summary and general discussion of thesis in English and in Dutch

Including: 'Artemisinine derivaten: een nieuwe therapie voor malaria'

Dankwoord

Curriculum vitae

Addendum

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