Genetic insights, clinical efficacy and practical implications of genetic screening for familial hypercholesterolemia

Authors	M.A.W. Umans-Eckenhausen
Supervisors	H.R. Büller J.J.P. Kastelein
Cosupervisors	J.C. Defesche
Award date	28-11-2002
ISBN	905170657X 9789051706574
Number of pages	165
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: CRIA
Language	English
Downloads	Thesis Cover Stellingen Titlepage Contents Introduction and overview of this thesis PART I GENETIC INSIGHTS Chapter 1 The molecular basis of familial hypercholesterolemia in The Netherlands Chapter 2 LDL-receptor gene mutations and cardiovascular risk in a large genetic cascade screening population Chapter 3 Review of first 5 years of screening for familial hypercholesterolaemia in The Netherlands Chapter 4 Better screening and better treatments - reducing the burden of familial hypercholesterolaemia PART II CLINICAL EFFICACY Chapter 5 Long-term compliance to lipid lowering medication after genetic screening for Familial Hypercholesterolemia Chapter 6 High-dose simvastatin in a lipid clinic setting: An audit of performance Chapter 7 A cost-effectiveness analysis of the genetic screening programme for familial hypercholesterolemia in The Netherlands PART III PRACTICAL IMPLICATIONS Chapter 8 Parental attitude towards genetic testing for Familial Hypercholesterolemia in children Chapter 9 Genetic screening in the Netherlands: Practical issues and implications for health policy Chapter 10 Summary Samenvatting Dankwoord Curriculum Vitae Cover
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