Anatomical and cellular reservoirs for HIV-1 during potent antiretroviral therapy

Thesis

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Titlepage

CONTENTS

CHAPTER 1 INTRODUCTION

CHAPTER 2 Enhanced penetration of indinavir in cerebrospinal fluid and semen after the addition of low-dose ritonavir

CHAPTER 3 Pharmacokinetic profile of nevirapine and indinavir in various fractions of seminal plasma

CHAPTER 4 Penetration of the nucleoside analogue abacavir into the male genital tract of HIV-1 infected men

CHAPTER 5 Increasing cerebrospinal fluid chemokine concentrations despite undetectable cerebrospinal fluid HIV-RNA in HIV-1-infected patients receiving antiretroviral therapy

CHAPTER 6 Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy

CHAPTER 7 OKT3 and IL-2 treatment for purging of the latent HIV-1 reservoir in vivo results in selective long-lasting CD4 z T cell depletion

CHAPTER 8 Improved long-term suppression of HIV-1 replication with a triple-class multidrug regimen compared to standard of care antiretroviral therapy

CHAPTER 9 Stable concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid during two years of therapy

CHAPTER 10 Summary and conclusions

CHAPTER 10 Samenvatting en conclusies

Co-authors

Dankwoord

Curriculum Vitae

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