Function and dysfunction of the mitochondrial and peroxisomal beta-oxidation systems in human cells and their functional interaction

Thesis

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Titlepage

Contents

Abbreviations

Table with the names and formulas of saturated and unsaturated fatty acids

1: General introduction

2: Resolution of the subcellularsite of very-long-chainfatty acid ß-oxidationin human skin fibroblasts using a novel approach.

3: ß-Oxidation of fatty acids in cultured human skin fibroblasts devoid of the capacity for oxidative phosphorylation.

4: A new method to identify carnitine/acylcarnitinetranslocase deficiency in digitonin-permeabilizedhuman skin fibroblasts using acetyl-L-carnitineas substrate.

5: Fatty acid ß-oxidation in peroxisomes and mitochondria: The first, unequivocal evidence forthe involvement of carnitine in shuttling propionyl-CoA from peroxisomes to mitochondria.

6: Direct evidence for the transport of propionyl units from peroxisomes to mitochondria in the form of propionyl-camitine.

Summary

Nederlandsesamenvatting

Nawoord

References

Publications

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