Effects of therapies on cytokine patterns in psoriasis

Thesis

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Titlepage

Abbreviations

Contents

Chapter 1 General introduction and aims of the thesis

Chapter 2 Ultraviolet-B irradiation decreases IFN-γ and increases IL-4 expression in psoriatic lesional skin in situ and in cultured dermal T cells derived from these lesions

Chapter 3 T cells in psoriatic lesional skin that survive conventional therapy with NB-UVB radiation display reduced IFN-γ expression

Chapter 4 Ultraviolet-B radiation induces a transient appearance of IL-4 positive neutrophils, which support the development of Th2 responses

Chapter 5 IL-4 expression by neutrophils in psoriasis lesional skin upon high dose UVB exposure

Chapter 6 Neutrophils infiltrating UVB-irradiated normal skin display high IL-10 expression

Chapter 7 In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin

Chapter 8 Clinical improvement in chronic plaque-type psoriasis lesions after narrow band-UVB therapy is accompanied by a decrease in the expression of interferon-y inducers, IL-12, IL-18 and IL-23

Chapter 9 Cyclosporine A and methotrexate are equally effective in reducing T cell numbers in psoriatic skin lesions but have no consistent effect on IFN-γ and IL-4 expression in psoriatic skin in situ

Chapter 10 Summary and Discussion

Nederlandse samenvatting

Curriculum vitae

Bibliography

Dankwoord

Colour figures

Stellingen behorende bij het proefschrift

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