Adaptive gene expression of endocarditis-causing viridans group streptococci and Staphilococcus aureus

Thesis

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Titlepage

Contents

Chapter 1: General Introduction.

Chapter 2: Native valve infective endocarditis: streptococcal and staphylococcal characteristics and the search for novel bacterial virulence traits.

Chapter 3: A simple procedure for the isolation of cloning vectors and endogenous plasmids from viridans group streptococci and Staphylococcus aureus.

Chapter 4: Wide-host-range shuttle vectors for the screening of regulated promoter activity in viridans group streptococci; isolation of a neutral pH regulated promoter.

Chapter 5: A shift from oral to blood pH is a stimulus for gene expression of endocarditis-causing Streptococcus gordonii, and induces protection against oxidative stress by activation of msrA.

Chapter 6: Isolation and characterization of promoter regions from Streptococcus gordonii CH1.

Chapter 7: Rapid multiplication of endocarditis-causing viridans group streptococci in platelet-fibrin clots is dependent on plasma components and streptococcal protease activity.

Chapter 8: Altered gene expression of Staphylococcus aureus upon interaction with human endothelial cells.

Chapter 9: General Discussion and Summary.

Chapter 10: Nederlandse Samenvatting

Dankwoord

Curriculum Vitae

List of publications

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