Asymmetric synthesis of the Roche ester and its derivatives by rhodium-INDOLPHOS-catalyzed hydrogenation
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| Publication date | 2008 |
| Journal | Advanced Synthesis & Catalysis |
| Volume | Issue number | 350 | 10 |
| Pages (from-to) | 1610-1614 |
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| Abstract | (S)-3-Hydroxy-2-methylpropionate, known as the Roche ester, and several of its derivatives were successfully synthesized through asymmetric rhodium-catalyzed hydrogenation, using INDOLPHOS (diisopropyl{1-[(S)-3,5-dioxa-4-phosphacyclohepta[2,1-a;3,4-a]dinaphthalen-4-yl]-3-methyl-2-indolyl}phosphine) as the chiral ligand, in excellent yield and the highest ee reported up to now (TOF over 5500 h-1 at 25 °C; up to 98% ee at -40 °C). |
| Document type | Article |
| Published at | https://doi.org/10.1002/adsc.200800209 |
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