| Authors |
-
V. Galbiati
-
S. Gibbs
-
E. Roggen
-
E. Corsini
|
| Publication date |
02-2018
|
| Journal |
Current protocols in toxicology
|
| Volume | Issue number |
75 | 1
|
| Pages (from-to) |
20.15.1-20.15.20
|
| Organisations |
-
Faculty of Dentistry (ACTA)
|
| Abstract |
Recently, an in vitro procedure, which combines the epidermal equivalent potency assay with assessment of IL-18 to provide a single test for identification and classification of skin sensitizers, was developed and validated. This unit will describe a simple in vitro method for estimation of the expected sensitization induction level interpolating in vitro EC50 and IL-18 SI2 values to predict LLNA EC3 and/or human NOEL from standards curves generated using reference contact allergens, based on the use of Reconstituted human Epidermis (RhE).
|
| Document type |
Article
|
| Language |
English
|
| Published at |
https://doi.org/10.1002/cptx.44
|
| Other links |
https://www.scopus.com/pages/publications/85059226990
|
|
Permalink to this page
|