Quantitative analysis of minimal residual disease by PCR in childhood acute lymphoid leukemia

Thesis

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Titlepage

LIST OF ABBREVIATIONS

TABLE OF CONTENTS

Chapter 1 GENERAL INTRODUCTION

Chapter 2 QUANTIFICATION OF MINIMAL RESIDUAL DISEASE IN CHILDREN WITH OLIGOCLONAL B-PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA INDICATES THAT THE CLONES THAT GROW OUT DURING RELAPSE HAVE THE SLOWEST RATE OF REDUCTION ALREADY DURING INDUCTION THERAPY

Chapter 3 MRD STUDIES ARE BENEFICIAL IN THE FOLLOW-UP OF TEL-AML1 PATIENTS WITH B-PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA

Chapter 4 THE TEL-AML1 RQ-PCR CAN REPLACE THE ANTIGEN-RECEPTOR BASED GENOMIC PCR IN CLINICAL MRD STUDIES IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Chapter 5 ACCURATE QUANTIFICATION OF MINIMAL RESIDUAL DISEASE AT DAY 15, BY REAL-TIME QUANTITATIVE POLYMERASE CHAIN REACTION, IDENTIFIES ALSO PATIENTS WITH B-PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA AT HIGH RISK FOR RELAPSE

Chapter 6 NO CLEAR RELATION BETWEEN IN VITRO DRUG RESISTANCE AND LEVEL OF MINIMAL RESIDUAL DISEASE (MRD) AS DETECTED BY PCR AT THE END OF INDUCTION THERAPY IN CHILDHOOD ALL

Chapter 7 EARLY DETECTION OF CENTRAL NERVOUS SYSTEM RELAPSE BY PCR IN CHILDREN WITH B-PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA

Chapter 8 SUMMARY, GENERAL DISCUSSION AND FUTURE PERSPECTIVES

Chapter 9 NEDERLANDSE SAMENVATTING

REFERENCES

DANKWOORD PUBLICATIONS CURRICULUM VITAE

PUBLICATIONS

CURRICULUM VITAE

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