Genetic markers for Mycobacterium tuberculosis : characterization and spread of the Beijing genotype

Thesis

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Stellingen

Titlepage

Contents

1 Introduction

1.1 The burden of tuberculosis

1.2 New perspectives in the molecular epidemiology of tuberculosis

1.3 Aims and contents of this thesis

2 Comparison of methods based on different molecular epidemiological markers for typing of Mycobacterium tuberculosis complex strains: interlaboratory study of discriminatory power and reproducibility

3 Discriminatory power and reproducibility of novel DNA typing methods for Mycobacterium tuberculosis complex strains

4 Use of variable-number tandem-repeat typing to differentiate Mycobacterium tuberculosis Beijing family isolates from Hong Kong and comparison with IS6110 restriction fragment length polymorphism typing and spoligotyping

5 Improvement of differentiation and interpretability of spoligotyping for Mycobacterium tuberculosis complex isolates by introduction of new spacer oligonucleotides

6 Genetic heterogeneity in Mycobacterium tuberculosis isolates reflected in IS6110 restriction fragment length polymorphism patterns as low-intensity bands

7 Definition of the Beijing/W lineage of Mycobacterium tuberculosis on the basis of genetic markers

8 Worldwide distribution of Beijing/W genotype Mycobacterium tuberculosis and associations with drug resistance: a collaborative study in 35 countries

9 Typical and atypical strains of the Mycobacterium tuberculosis Beijing genotype have different levels of association with BCG vaccination and drug resistance

10 Discussion

Summary

Samenvatting

Dankwoord/acknowledgements

Curriculum vitae

List of Publications

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