Singly hydrogen bonded supramolecular ligands for highly selective rhodium-catalyzed hydrogenation reactions
| Authors |
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| Publication date |
2009
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| Journal |
Angewandte Chemie, International Edition
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| Volume | Issue number |
48 | 12
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| Pages (from-to) |
2162-2165
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| Organisations |
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Faculty of Science (FNWI) - Van 't Hoff Institute for Molecular Sciences (HIMS)
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| Abstract |
H bonds make the catalysts! A single hydrogen bond between ligands coordinated to a rhodium center is critical for the formation of pure supramolecular catalysts for asymmetric hydrogenation reactions. The ester group of the amidite ligand (see scheme) also forms a hydrogen bond with the coordinated substrate. Use of the heterocomplex afforded the highest enantioselectivity reported to date for the hydrogenation of several ester substrates.
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| Document type |
Article
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| Published at |
https://doi.org/10.1002/anie.200806177
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