Merobatzelladines A and B, Anti-Infective Tricyclic Guanidines from a Marine Sponge Monanchora sp.
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| Publication date | 2009 |
| Journal | Organic Letters |
| Volume | Issue number | 11 | 12 |
| Pages (from-to) | 2655-2658 |
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| Abstract | Merobatzelladines A (1) and B (2) have been isolated from a marine sponge Monanchora sp. as antibacterial constituents. Their structures including relative stereochemistry were determined by interpretation of spectral data. The absolute stereochemistry of merobatzelladine B (2) was elucidated after introduction of the fourth ring system preinstalled with a secondary hydroxyl group to which the modified Mosher method was applied. Merobatzelladines exhibit moderate anti-infective activity against a bacterium and protozoa. |
| Document type | Article |
| Language | English |
| Published at |
https://doi.org/10.1021/ol9006794
(Final published version)
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