Novel treatment strategies for hereditary breast cancer

Authors	B. Evers
Supervisors	A.J.M. Berns
Co-supervisors	J.M.M. Jonkers
Award date	3 July 2009
ISBN	9789075575224
Number of pages	148
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Front cover Title pages Table of contents Chapter 1: Mouse models of BRCA1 and BRCA2 deficiency : past lessons, current understanding and future prospects Chapter 2: Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin Chapter 3: A high throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2 deficient tumors Chapter 4: Novel compounds with specific toxicity against BRCA2 deficient tumor cells Chapter 5: A mouse mammary gland reconstitution model to assess the contribution of cancer cell-intrinsic and -extrinsic factors to mammary tumorigenesis Chapter 6: Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium Chapter 7: General discussion English summary Nederlandse samenvatting Curriculum vitae Publications Dankwoord
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