The development of new treatment strategies for oesophageal cancer

Thesis

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Titlepage

preface

list of contents

part I General introduction

Chapter 1 Current insight into the molecular biology of Barrett's oesophagus and its potential clinical application

part II Optimizing diagnostic tools for tailored therapeutic decision making

Chapter 2 Histopathologic features of HGD and early adenocarcinoma of the oesophagus predicting eligibility for local endoscopic treatment

Chapter 3 Clinical significance of immunohistochemically detected micrometastases in histologically negative lymph nodes of patients with adenocarcinoma of the distal oesophagus or gastric cardia

part III Prognostic and therapeutic potential of cyclooxygenase-2

Chapter 4 The role of Cyclooxygenase-2 in the development and treatment of oesophageal adenocarcinoma

Chapter 5 Prognostic significance of elevated cyclooxygenase-2 expression in patients with adenocarcinoma of the oesophagus

Chapter 6 Comparison of cyclooxygenase-2 expression in adenocarcinomas of the gastric cardia and distal oesophagus

Chapter 7 Cyclooxygenase-2 as a prognostic factor for neo-adjuvant-treated patients with squamous cell carcinoma of the oesophagus

Chapter 8 Selective cyclooxygenase-2 inhibition as neo-adjuvant therapy for patients with oesophageal adenocarcinoma

part IV Development of efficient and selective gene therapy

Chapter 9 The current status of cancer gene therapy and its application in oesophageal carcinoma

Chapter 10 A genetically retargeted adenoviral vector enhances viral transduction in oesophageal carcinoma cell lines and primary cultured oesophageal resection specimens

Chapter 11 Gene therapy for oesophageal carcinoma: the use of an explant model to test adenoviral vectors ex vivo

Chapter 12 Histopathologic evaluation of an animal model for Barrett's oesophagus and adenocarcinoma of the distal oesophagus

Chapter 13 Inflammation mediated activation compromises tumour specificity of the Cyclooxygenase-2 promoter in adenoviral context

part V Summary Conclusions and Epilogue

Chapter 14 Summary/Samenvatting

Chapter 15 Epilogue

appendices

ACKNOWLEDGEMENTS/DANKWOORD

STELLINGEN

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