The pivotal role of CTP synthetase in the metabolism of (deoxy)nucleosides in neuroblastoma

Authors	J. Bierau
Supervisors	H.N. Caron
Cosupervisors	A.B.P. van Kuilenburg A.H. van Gennip
Award date	21-05-2003
ISBN	9064646198 9789064646195
Number of pages	136
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: GEMO
Language	English
Downloads	Thesis Cover Titlepage Contents Abbreviations Chapter 1 Introduction Chapter 2 The effects of cyclopentenyl cytosine on human neuroblastoma cell lines Chapter 3 Cyclopentenyl cytosine primes SK-N-BE(2)c neuroblastoma cells for cytarabine toxicity Chapter 4 Cyclopentenyl cytosine sensitises SK-N-BE(2)c neuroblastoma cells to cladribine Chapter 5 Gemcitabine and cyclopentenyl cytosine: a promising combination for the treatment of neuroblastoma Chapter 6 Retinoic acid reduces the cytotoxicity of cyclopentenyl cytosine in neuroblastoma cells Chapter 7 Determination of the deoxycytidine kinase activity in cell homogenates with a non-radiochemical assay using reversed-phase high performance liquid chromatography. Identification of a novel metabolite of 2-Chlorodeoxyadenosine. Chapter 8 General discussion and recommendations Summary Samenvatting voor iedereen Dankwoord Publications Cover
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