| Abstract |
This thesis focused on optimizing treatment for type 2 diabetes. We evaluated short-term risk (hypoglycaemia) and long-term risk (cancer) of sulfonylurea derivatives and insulin and reviewed the (dis)advantages of the long-acting insulin analogues, insulin glargine and insulin detemir. Furthermore, we evaluated strategies to optimize insulin dose titration. In particular we investigated the feasibility, safety and effectiveness of an e-health application with computerised decision support to support patients in performing insulin titration.
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