Asymmetric hydrogenation of enamides, α-enol and α-enamido ester phosphonates catalyzed by IndolPhos-Rh complexes
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| Publication date | 2009 |
| Journal | Journal of Organic Chemistry |
| Volume | Issue number | 74 | 21 |
| Pages (from-to) | 8403-8406 |
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| Abstract | The scope of the IndolPhos-Rh-catalyzed asymmetric hydrogenation of enamides, α-enol and α-enamido ester phosphonates, has been investigated. In addition, Taddol-based IndolPhos ligands are introduced. High activities and good to excellent enantioselectivities up to 99% ee are obtained for a broad range of structurally diverse substrates, giving important chiral products such as α, β2, and β3 amino acid derivatives, arylamines, and amino and hydroxy phosphonates. |
| Document type | Article |
| Published at | https://doi.org/10.1021/jo9018683 |
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