Studies on puupehenone-metabolites of a Dysidea sp.: structure and biological activity

Authors
  • M.L. Ciavatta
  • M.P. Lopez Gresa
  • M. Gravagnin
  • V. Romero
Publication date 2007
Journal Tetrahedron
Volume | Issue number 63
Pages (from-to) 1380-1384
Number of pages 5
Organisations
  • Faculty of Science (FNWI)
Abstract Abstract—Puupehenone (1) and a series of its congeners (2-6) have been isolated from a Dysidea sponge. The unprecedented 20-acetoxyhaterumadienone (2) exhibiting a five-membered contracted ring, has been characterized. In addition, stereochemical assignment of two previously reported acetone adducts of puupehenone (5 and 6) has been made. Finally, the inhibition of mitochondrial respiratory chain as well as antibacterial and antifungal activities of all compounds has been evaluated.
Document type Article
Published at https://doi.org/10.1016/j.tet.2006.11.088
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