The dynamics of haemostasis and endothelial function

Thesis

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Titlepage

CONTENTS

1 GENERAL INTRODUCTION

2 THE VARIABLE REGION-1 FROM TISSUE-TYPE PLASMINOGEN ACTIVATOR CONFERS SPECIFICITY FOR PLASMINOGEN ACTIVATOR INHIBITOR-1 TO THROMBIN BY FACILITATING CATALYSIS: RELEASE OF A KINETIC BLOCK BY A HETEROLOGOUS PROTEIN SURFACE LOOP

3 A STEADY-STATE COMPETITION MODEL DESCRIBES THE MODULATING EFFECTS OF THROMBOMODULIN ON THROMBIN INHIBITION BY PLASMINOGEN ACTIVATOR INHIBITOR-1 IN THE ABSENCE AND PRESENCE OF VITRONECTIN

4 PROLONGED FLUID SHEAR STRESS INDUCES A DISTINCT SET OF ENDOTHELIAL CELL GENES, MOST SPECIFICALLY LUNG KRÜPPEL-LIKE FACTOR (KLF2)

5 CORRELATION OF THE IN VIVO ENDOTHELIAL EXPRESSION OF LUNG KRÜPPEL-LIKE FACTOR (LKLF) WITH LOCAL BIOMECHANICAL STRESSES

6 SHEAR STRESS AND NITRIC OXIDE SENSITIZE THE ENDOTHELIAL TRANSCRIPTIONAL RESPONSE OF DISTINCT GENE PANELS TO THE INFLAMMATORY CYTOKINES TNF- AND IL-1

7 GENERAL DISCUSSION

8 SUMMARY & SAMENVATTING

CURRICULUM VITAE, PUBLICATIELIJST, DANKWOORD

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