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Studies on the immune system in CLL

Open Access
Authors
  • R. Mous
Supervisors
  • M.H.J. van Oers
  • R.A.W. van Lier
Cosupervisors
  • E.F. Eldering
Award date 03-10-2008
ISBN
  • 9789088910623
Number of pages 165
Organisations
  • Faculty of Medicine (AMC-UvA)
Document type PhD thesis
Note Research conducted at: Universiteit van Amsterdam
Language English
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Thesis
Cover
Titlepage
Contents
Chapter 1: Introduction: CLL, a paradigm of tumor-associated immune dysfunction
Chapter 2: Enhanched survival of regulatory T cells inCLL
Chapter 3: Detection of p53 dysfunction in chronic lymphocytic leukemia cells via multiplex quantification of p53 target gene induction
Chapter 4: Redirection of CMV specific CTL towards CLL via CD20 targeted HLA/CMV complexes
Chapter 5: Adequate synapse formation between leukemic B cells and effector T cells following stimulation with artificial TCR ligands
Chapter 6: Granzyme B induced apoptosis is enhanced by small molecule inhibitors of XIAP
Chapter 7: Summary and discussion
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