Expression profiling in head and neck cancer: Predicting response to chemoradiation

Authors	J. Pramana
Supervisors	M.W.M. van den Brekel A.C. Begg
Cosupervisors	C.R.N. Rasch A.J.M. Balm
Award date	17-10-2014
Number of pages	135
Organisations	Faculty of Dentistry (ACTA)
Abstract	The goal of this thesis was to find biomarkers through gene expression profiling, using microarray techniques, which can predict outcome after concurrent chemoradiation in head and neck cancer. The main endpoints for outcome were local control, locoregional control and disease free survival.
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis (complete) Front matter Chapter 1: Introduction and outline of the thesis Chapter 2: Heterogeneity of gene expression profiles in head and neck cancer Chapter 3: Gene expression profiling to predict outcome after chemoradiation in head and neck cancer Chapter 4: A gene expression model of intrinsic tumor radiosensitivity: Prediction of response and prognosis after chemoradiation Chapter 5: HPV and high risk gene expression profiles predict response to chemoradiation in head and neck cancer, independent of clinical factors Chapter 6: EGFR expression predicts unfavourable survival in advanced HPV-positive oropharyngeal cancer treated with chemoradiation Chapter 7: General discussion Chapter 8: Summary/Samenvatting Appendices Stellingen
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