Combining radiotherapy with death ligands in cancer treatment : feasibility and molecular mechanisms

Authors	I. Verbrugge
Supervisors	J. Borst M. Verheij
Award date	19-06-2009
ISBN	9789085702849
Number of pages	108
Organisations	Faculty of Science (FNWI) - Swammerdam Institute for Life Sciences (SILS)
Document type	PhD thesis
Note	Research conducted at: NKI-AvL
Language	English
Downloads	Thesis Cover Title pages Contents Chapter 1: General introduction Chapter 2: TRAIL enhances efficacy of radiotherapy in a p53 mutant, Bcl-2 overexpressing lymphoid malignancy Chapter 3: Ionizing radiation modulates the TRAIL death-inducing signaling complex, allowing bypass of the mitochondrial apoptosis pathway Chapter 4: Combining radiotherapy with APO010 in cancer treatment Chapter 5: Radiation and anti-cancer drugs facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation Chapter 6: TRAIL-receptor-1 and -2 plasma membrane levels are differentially regulated by dynamin-dependent endocytosis and MARCH family ubiquitin ligases Chapter 7: General discussion Summary Nederlandse samenvatting List of publications Curriculum vitae Dankwoord
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